Developmental pharmacology--drug disposition, action, and therapy in infants and children.
نویسندگان
چکیده
From the Departments of Pediatrics (G.L.K., S.M.A.-R., S.W.A., D.L.B., J.S.L., R.E.K.), Pharmacology (G.L.K., D.L.B., J.S.L., R.E.K.), and Pharmacy Practice (S.M.A.-R.), University of Missouri at Kansas City; and the Divisions of Pediatric Pharmacology and Medical Toxicology (G.L.K., S.M.A.-R., S.W.A., D.L.B., J.S.L., R.E.K.), Emergency Medicine (S.W.A.), and Nephrology (D.L.B.), Children’s Mercy Hospitals and Clinics — both in Kansas City, Mo. Address reprint requests to Dr. Kearns at the Division of Pediatric Pharmacology and Medical Toxicology, Department of Pediatrics, Children’s Mercy Hospitals and Clinics, 2401 Gillham Rd., Kansas City, MO 64108, or at gkearns@ cmh.edu.
منابع مشابه
Developmental pharmacokinetics.
The advances in developmental pharmacokinetics during the past decade reside with an enhanced understanding of the influence of growth and development on drug absorption, distribution, metabolism, and excretion (ADME). However, significant information gaps remain with respect to our ability to characterize the impact of ontogeny on the activity of important drug metabolizing enzymes, transporte...
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Although nontherapeutic xenobiotics represent the vast majority of environmental exposures during childhood, study of these compounds in children has lagged behind drug studies. Some useful extrapolation can be made from the latter, however. An increased impetus for pediatric pharmacology studies resulted from evidence of shortcomings in algorithmic approaches to dosing and the recognition of d...
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The advances in developmental pharmacokinetics during the past decade reside with an enhanced understanding of the influence of growth and development on drug absorption, distribution, metabolism, and excretion (ADME). However, significant information gaps remain with respect to our ability to characterize the impact of ontogeny on the activity of important drug metabolizing enzymes, transporte...
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Background: Developmental and behavioral disorders are the most prevalent problems in children after infection and trauma. Growth and development are influenced by genetic, social and environmental factors that incept of the early life of the fetal and neonatal periods. Due to the importance of the development in children, this study was conducted to determine the relationship between growth in...
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Quinine is the best studied drug for treating severe malaria in very young children. Quinine may be administered in pregnancy and, at therapeutic doses, malformations have not been reported. Some strains of quinine from Southeast Asia and South America have become resistant. Quinine is the treatment of choice for the drug-resistant severe Plasmodium falciparum. The antimalarial mechanism of qui...
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ورودعنوان ژورنال:
- The New England journal of medicine
دوره 349 12 شماره
صفحات -
تاریخ انتشار 2003